ImmunologybioRxivPreprint
GDF15 mediates inflammation-associated bone loss through a brain-bone axis
Renée Van der Cruyssen, Jan Devan, Irina Heggli…·Dirk Elewaut
This study identifies GDF15 as a mediator of inflammation-associated bone loss via a brain-bone axis, showing it induces bone loss through GFRAL receptor activation in the hindbrain.
DOI 10.1101/2023.11.22.568290