Author

George G. Harmison

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Audrey M. WinkelsasiD· 2 shared Christopher GrunseichiD· 2 shared Adam Comer· 1 shared Adnan Yousaf Manzur· 1 shared Aileen Reghan FoleyiD· 1 shared Alayne P. MeyeriD· 1 shared Andrew D. NguyeniD· 1 shared Aneesh G. PatankariD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Audrey M. WinkelsasORCID

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2 papers

Recent·Most cited

A class of deep intronic IGHMBP2 variants activate a shared cryptic splice donor, enabling correction of select variants with a single antisense oligonucleotide

Sarah Silverstein, Andrew D. Nguyen, Rotem Orbach, Sandra C. Donkervoort, Thomas A. Cassini, Mary E. Koziura, Véronique Bolduc, Audrey M. Winkelsas, Ester Masati, Shreya Nandi, George G. Harmison, BE Johnson, Kory Johnson, Sarah E. Kargbo-Hill, Jason J. Bussgang, , Christopher Grunseich

This study identifies deep intronic IGHMBP2 variants causing SMARD1 and CMT2S, showing they activate a shared cryptic splice donor, enabling correction with a single antisense oligonucleotide in patient-derived motor neurons.

medRxiv · Apr 29, 2026 · PreprintGenetic & Genomic Medicine

Allele-specific silencing of a dominant SETX mutation in familial amyotrophic lateral sclerosis type 4

Audrey M. Winkelsas, Athena Marie Apfel, Brian Johnson, George G. Harmison, Kimberly K. Diaz Perez, Dongjun Li, Vivian G. Cheung, Christopher Grunseich

The paper demonstrates that allele-specific siRNA can effectively silence a dominant SETX mutation in ALS4, restoring R-loop levels in patient cells.

Human Genetics and Genomics Advances · Apr 8, 2025Peer-reviewedGenetics