SHP2 Inhibition Abrogates MEK inhibitor Resistance in Multiple Cancer Models
Carmine Fedele, Hao Ran, Brian Diskin, Wei Wei, Jayu Jen, Kiyomi Araki, Diane M Simeone, George Miller, Benjamin G Neel, Kwan Ho Tang
This study shows that combining SHP2 and MEK inhibitors overcomes adaptive resistance in multiple cancer models, including KRAS-mutant and wild-type RAS cancers.
bioRxiv · Apr 25, 2018 · PreprintCancer Biology