Iso-relevance Functions - A Systematic Approach to Ranking Genomic Features by Differential Effect Size
Soumyashant Nayak, Nicholas F. Lahens, Eun Ji Kim, Emanuela Ricciotti, George Paschos, Sarah A. Tishkoff, Dimitra Sarantopoulou, Shaon Sengupta, Barry S. Cooperman, Tilo Großer, Gregory R. Grant
The paper introduces a framework to rank genomic features by differential effect size, showing that pseudocounts optimize the balance between fold-change and difference sorting.
bioRxiv · Feb 5, 2019 · PreprintBioinformatics