Barry S. Cooperman

This paper identifies new TRIDs that target ribosome pockets to increase PTC readthrough, showing some are more potent than ataluren in vitro.

This study identifies active transport of tRNAs via endolysosomal vesicles in large cells, showing that LeuRS facilitates this process and its disruption impairs protein synthesis and cell size.

This study uses single-molecule techniques to analyze tRNA selection during eukaryotic translation, revealing faster near-cognate sampling and a negative correlation between near-cognate concentration and tRNA accommodation efficiency.

This study identifies cyclic peptides that suppress nonsense mutations in yeast, showing high readthrough activity and low cytotoxicity, suggesting potential as novel therapeutics for genetic diseases.

This paper investigates how PTC identity and sequence context affect readthrough efficiency and ataluren's effectiveness, providing insights into patient-specific therapy design.

The paper introduces a framework to rank genomic features by differential effect size, showing that pseudocounts optimize the balance between fold-change and difference sorting.