Emanuela Ricciotti

Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use

The paper shows that suppressing both COX-1 and COX-2 does not cause intestinal injury in mice unless combined with specific NSAIDs, and that gut microbiome changes amplify NSAID-induced enteropathy.

Sources of non-uniform coverage in short-read RNA-Seq data

This study investigates sources of non-uniform coverage in RNA-Seq data and finds that no single factor explains the issue, contradicting prior claims.

Metabolomic Response to Non-Steroidal Anti-Inflammatory Drugs

This study compares the metabolomic effects of naproxen and celecoxib in humans and mice, finding that naproxen reduces tryptophan levels independently of Cox-2 inhibition.

Cyclooxygenase-2 disruption predisposes to heart failure with preserved ejection fraction

This study shows that COX-2 deletion or inhibition leads to heart failure with preserved ejection fraction in zebrafish, mice, and humans.

Disruption of the PGE2 synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice

This study shows that disrupting the PGE2 synthesis or response pathway reduces atherogenesis in PD-1 deficient hyperlipidemic mice through different immune mechanisms.

Deep Phenotyping of the Lipidomic Response in COVID and non-COVID Sepsis

The paper identifies lipidomic biomarkers and therapeutic targets in sepsis patients, including those with COVID-19, and develops an interactive network analysis tool for multiomic data exploration.

Distinct vascular genomic response of proton and gamma radiation.

This study compares the genomic response of mouse aorta to proton and gamma radiation, finding differences in gene responsiveness and pathway activation.

Iso-relevance Functions - A Systematic Approach to Ranking Genomic Features by Differential Effect Size

The paper introduces a framework to rank genomic features by differential effect size, showing that pseudocounts optimize the balance between fold-change and difference sorting.