Glycan-Mediated Mechanosensing Regulates Megakaryocyte-Biased Hematopoietic Stem Cell Subsets.
Alejandro Roisman, Leonardo Rivadeneyra, Lindsey R. Conroy, Melissa M. Lee‐Sundlov, Natalia Weich, Simon H. Glabere, Shikan Zheng, Katelyn E. Rosenbalm, Mark Zogg, George Steinhardt, Anthony J. Veltri, Joseph T.Y. Lau, Tongjun Gu, Hartmut Weiler-Guettler, Ramon C. Sun, Karin M. Hoffmeister
This study identifies B4GALT1 as a key regulator of HSPC lineage decisions by modulating glycosylation and mechanosensing in the bone marrow niche.
bioRxiv · Jan 25, 2025 · PreprintCell Biology