Ramon C. Sun

One-carbon metabolism sustains effector T cell function through cell-surface glycosylation

This study shows folate deprivation impairs CD8+ T cell function by disrupting cell surface glycosylation, and increasing folate uptake enhances T cell anti-tumor activity.

Closed-head injury produces a delayed, region-specific defect in glucose-carbon routing at the pyruvate branchpoint in APP/PS1 KI mice

The paper investigates delayed glucose metabolism changes in APP/PS1 KI mice after closed-head injury, finding increased pyruvate and lactate labeling in cortex and hippocampus 8 months post-injury.

Systemic hypoxia drives glycogen-fueled progression of lung adenocarcinoma

This study shows systemic hypoxia promotes lung adenocarcinoma progression by mobilizing glycogen via GAA, supporting tumor growth through metabolic remodeling.

The liver compensates for zonal loss of glucose 6-phosphatase to prevent glycogen storage disease

This study shows that localized loss of G6pc1 in liver zones causes local glycogen accumulation but not systemic disease, highlighting organ-wide compensation for metabolic homeostasis.

Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibition attenuates abdominal aortic aneurysm formation via enhanced macrophage-dependent efferocytosis

This study shows PCSK9 inhibitors reduce AAA growth by enhancing macrophage efferocytosis through MerTK-dependent mechanisms and altering lipid metabolism in the aortic wall.

A multi-organ spatial metabolomic atlas of exercising mice reveals neuronal Complex I as a convergent and sufficient axis for tau pathology reduction in PS19

This paper constructs a spatial metabolomic atlas of exercise in mice, identifies Complex I as a key target for reducing tau pathology, and shows that enhancing its activity mimics exercise's protective effects.

Reference-Informed Spatial Domain Detection Using Weak Supervision for Spatial Transcriptomics

This paper introduces GraphScrDom, a contrastive learning model for spatial domain detection in spatial transcriptomics using weak supervision and reference data, showing strong performance across platforms and resolutions.

Metabolic Coherence of the Mouse Brain

The paper maps spatial metabolome coherence across mouse brain regions using MALDI imaging and optimal transport, showing preserved coherence in Alzheimer's model despite metabolic changes and demonstrating intervention effects.

A novel subset of hepatocytes is simultaneously gluconeogenic and de novo lipogenic in the fed state and is naturally insulin resistant

A real-world cohort study of immune-related adverse events in patients receiving immune checkpoint inhibitors

This study identifies risk factors and patterns of immune-related adverse events (irAEs) in patients receiving immune checkpoint inhibitors using real-world data.

BayesCNet: Bayesian inference for cell type-specific regulatory networks leveraging cell type hierarchy in single-cell data

BayesCNet improves inference of cell type-specific regulatory networks by leveraging cell type hierarchy, outperforming existing methods, especially for rare cell types.

Neonatal systemic gene therapy restores cardiorespiratory function in a rat model of Pompe disease

Hyper-Glycosylation as a Central Metabolic Driver of Alzheimers Disease

This study identifies hyper-glycosylation as a driver of Alzheimer's disease through metabolic analysis and interventions, showing its impact on cognitive decline and mortality.

Glycan-Mediated Mechanosensing Regulates Megakaryocyte-Biased Hematopoietic Stem Cell Subsets.

This study identifies B4GALT1 as a key regulator of HSPC lineage decisions by modulating glycosylation and mechanosensing in the bone marrow niche.

Cortical inhibitory parvalbumin interneurons exhibit metabolic specializations coordinated by PGC-1α that are lost in rodents and humans after traumatic brain injury

The paper shows that PV-INs have unique metabolic specializations lost after TBI, which can be rescued by 2-deoxyglucose, and identifies PGC-1α and lncRNAs as key factors in this dysfunction.

MetaVision3D: Automated framework for the Generation of Spatial Metabolome Atlas in 3D

MetaVision3D converts serial 2D MALDI mass spectrometry imaging sections into a 3D spatial metabolome atlas using computer vision techniques.

GalNAc-siRNA Mediated Knockdown of Ketohexokinase Versus Systemic, Small Molecule Inhibition of its Kinase Activity Exert Divergent Effects on Hepatic Metabolism in Mice on a HFD

This study compares the effects of GalNAc-siRNA-mediated KHK knockdown and small molecule KHK inhibition on hepatic metabolism in mice on a high-fat diet, finding divergent impacts on lipid metabolism and glucose tolerance.

Spatial Metabolome Lipidome and Glycome from a Single brain Section

The paper presents a method for simultaneous spatial analysis of metabolome, lipidome, and glycome from a single tissue section using mass spectrometry imaging and a computational framework called Sami.

Targeting the Microbiome to Improve Gut Health and Breathing Function After Spinal Cord Injury

This paper shows that probiotic treatment after spinal cord injury improves gut health and respiratory function by reducing inflammation and enhancing neuronal regeneration.

APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge

This study investigates how APOE4 affects microglial immunometabolism across age, amyloid pathology, and inflammation using multi-omics approaches.

Sex and APOE Genotype Influence Respiratory Function Under Hypoxic and Hypoxic-Hypercapnic Conditions

This study shows that sex and APOE genotype affect breathing during hypoxia, with female mice showing impaired recovery.

APOE4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis

This study identifies APOE4-associated metabolic changes in brain and systemic metabolism, showing increased aerobic glycolysis and reduced oxidative metabolism in both mice and humans.

Cervical Spinal Cord Injury Leads to Injury and Metabolic Dysfunction of the Lung

This study shows that cervical spinal cord injury in rats leads to acute lung injury and metabolic dysfunction, establishing a new animal model for studying this relationship.

Multi-Dimensional Reduction Clustering of Complex Carbohydrates Reveal Tissue Metabolism, Heterogeneity and Histopathology

The paper introduces Madi, a workflow combining MALDI-MSI and machine learning to analyze FFPE tissues, revealing metabolic patterns and pathological features in human tissues.