Cure of experimental Trypanosoma vivax infection with a single dose of an unmodified antibody-based drug targeting the invariant flagellum cell surface protein IFX
Delphine Autheman, Cristina Viola, Georgina Rhodes, Simon Clare, Cordelia Brandt, Katherine Harcourt, Gavin James Wright
This paper shows that a single dose of an unmodified anti-IFX monoclonal antibody can cure T. vivax infections in mice, with no detectable parasites in peripheral tissues.
mBio · Oct 20, 2025Peer-reviewedMicrobiology