Simon Clare

SET1B drives sustained HIF activity and disease progression in clear cell renal cell carcinoma.

This study shows SET1B maintains HIF activity in ccRCC, correlates with disease progression, and is a target for HIF-2 inhibitors.

Development and evaluation of a dual target glycoconjugate vaccine against Shigella sonnei

This paper develops a dual-target glycoconjugate vaccine against Shigella sonnei using a carrier protein and O-antigen, showing it elicits IgG responses to both components.

In vivo screening reveals new regulators of Natural Killer cell development and functional response to acute cytomegalovirus infection

The paper identifies novel regulators of NK cell development and antiviral function through in vivo screening in mice, with relevance to human health.

Cure of experimental Trypanosoma vivax infection with a single dose of an unmodified antibody-based drug targeting the invariant flagellum cell surface protein IFX

This paper shows that a single dose of an unmodified anti-IFX monoclonal antibody can cure T. vivax infections in mice, with no detectable parasites in peripheral tissues.

Intestinal challenges shape the polarisation of protective dural memory CD4 T cells

This study shows that intestinal immunological challenges shape the polarization of dural CD4 T cells, which provide protective memory against pathogens.

Host microbiome determines host specificity of the human whipworm, Trichuris trichiura

This study shows that the human whipworm's host specificity is driven by the host microbiome, using a humanized-microbiota mouse model and metagenomic analysis.

Mechanisms of maternal antibody interference to rotavirus vaccination

This study investigates how maternal antibodies interfere with rotavirus vaccination in neonates using a mouse model, finding that vaccine clearance rather than FcγRIIB signaling or epitope masking is the main mechanism of interference.

Simultaneously inferring T cell fate and clonality from single cell transcriptomes

This paper introduces TraCeR, a method to infer full-length TCR sequences from single-cell RNA-seq, revealing clonal relationships and linking them to T cell functional states in Salmonella infection.