Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs
Peter J. West, Kyle E. Thomson, Peggy Billingsley, Timothy H. Pruess, Carlos B. Rueda, Gerald W. Saunders, Misty D. Smith, Cameron S. Metcalf, Karen S. Wilcox
This paper evaluates the pharmacoresistance of spontaneous seizures in an intra-amygdala kainate model of temporal lobe epilepsy to various antiseizure drugs, finding resistance to sodium channel inhibitors but sensitivity to GABA modulators and valproate.
Experimental Neurology · Dec 16, 2021Peer-reviewedNeuroscience