Kyle E. Thomson

This study evaluates the efficacy of stiripentol add-on to clobazam and valproic acid in a Scn1aA1783V/WT mouse model of Dravet syndrome, showing reduced seizure frequency and therapeutic plasma concentrations.

The paper shows that interictal epileptiform discharges (IEDs) are bidirectional traveling waves that follow the same path and direction as ictal discharges, suggesting they originate outside the seizure focus.

This paper evaluates the pharmacoresistance of spontaneous seizures in an intra-amygdala kainate model of temporal lobe epilepsy to various antiseizure drugs, finding resistance to sodium channel inhibitors but sensitivity to GABA modulators and valproate.