Poldip2 deficiency attenuates disease severity in a mouse model of COVID-19
Ruinan Hu, Alejandra Valdivia, Taylor E. White, Willy Ju, Maegan L. Brockman, Zhan Zhang, Hongyan Qu, Georgette M. Gafford, Giji Joseph, Samantha Burton, Leda Bassit, Tysheena P. Charles, Rebecca D. Levit, Cynthia A. Derdeyn, Kathy K. Griendling, , Marina S. Hernandes
This study shows that Poldip2 deficiency reduces lung inflammation and tissue damage in a mouse model of SARS-CoV-2 infection without affecting viral susceptibility.
bioRxiv · Jun 17, 2025 · PreprintPathology