Molecular BiologyACS Infectious DiseasesPeer-reviewed
Systematic analyses of the resistance potential of drugs targeting SARS-CoV-2 main protease
Julia M. Flynn, Qiu Yu J. Huang, Sarah N. Zvornicanin…·Daniel N. A. Bolon
The paper identifies resistance mutations in SARS-CoV-2 main protease against nirmatrelvir and ensitrelvir using yeast screens, finding cross-resistant mutations and reduced enzyme function.
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