Author

Giovanni Cercignani

National Research Council

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alice ChiodiiD· 2 shared Beatrice CampanellaiD· 2 shared Elena LevantiniiD· 2 shared Emilia BramantiiD· 2 shared Ettore MoscaiD· 2 shared Eva Cabrera San MillániD· 2 shared Giorgia MaroniiD· 2 shared Giulia BracciniiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Alice ChiodiORCID

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2 papers

Recent·Most cited

Deciphering the Role of Acetate in Metabolic Adaptation and Drug Resistance in Non-Small Cell Lung Cancer

Giorgia Maroni, Eva Cabrera San Millán, Beatrice Campanella, Massimo Onor, Giovanni Cercignani, Beatrice Muscatello, Giulia Braccini, Raffaella Mercatelli, Alice Chiodi, Ettore Mosca, Elena Levantini, Emilia Bramanti

This study identifies a metabolic adaptation in osimertinib-resistant NSCLC cells involving acetate production via a PAA shunt, which supports redox balance and bioenergetics.

bioRxiv · Jul 4, 2025 · PreprintBiochemistry

Reprogramming of Osimertinib-Resistant EGFR-mutant NSCLC: The Pyruvate-Acetaldehyde-Acetate Pathway As a Key Driver of Resistance

Giorgia Maroni, Eva Cabrera San Millán, Raffaella Mercatelli, Alice Chiodi, Beatrice Campanella, Massimo Onor, Letizia Modeo, Giulia Braccini, Giovanni Cercignani, Azhar Ali, Ettore Mosca, Emilia Bramanti, Elena Levantini

This study identifies metabolic reprogramming in osimertinib-resistant EGFR-mutant NSCLC, highlighting the pyruvate-acetaldehyde-acetate pathway and mitochondromic alterations as key drivers of resistance.

bioRxiv · Jun 27, 2025 · PreprintCancer Biology