Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients
Alfonsina D’Amato, Lorenzo Di Cesare Mannelli, Elena Lucarini, Angela Man, Gwénaëlle Le Gall, Jacopo Junio Valerio Branca, Carla Ghelardini, Amedeo Amedei, Eugenio Bertelli, Marì Regoli, Alessandra Pacini, Giulia Luciani, Pasquale Gallina, Annalisa Altera, Arjan Narbad, , Claudio Nicoletti
This study shows that FMT from aged mice impairs spatial learning in young recipients by altering hippocampal proteins related to synaptic plasticity and neurotransmission.
Microbiome · Oct 1, 2020Peer-reviewedNeuroscience