Gwénaëlle Le Gall

Dietary fibre combinations modulate gut microbiome composition and metabolic responses in zebrafish, with lasting effects on intestinal barrier gene expression

This study shows that combining apple pectin and cellulose in zebrafish diets leads to non-additive gut microbiome changes and lasting intestinal barrier effects.

Dietary fibre responses emerge through host-dietary regime interplay: Apple pectin modulates immune reactivity in adult zebrafish

This study examines how different dietary fibre regimes affect the gut microbiome, SCFA profiles, and immune responses in zebrafish, showing context-specific effects influenced by sex and dietary context.

Cerebrovascular damage caused by the gut microbe-derived uraemic toxin p-cresol sulfate isprevented by blockade of the epidermal growth factor receptor

This study shows p-cresol sulfate impairs the blood-brain barrier via EGFR activation and demonstrates EGFR blockade prevents this damage in vitro.

Gum Arabic (Acacia senegal) enhances reproduction and modulates the microbiota-gut-brain axis of zebrafish in a sex-specific and dosage-dependent manner

This study shows that gum Arabic improves gut microbiota and brain metabolism in zebrafish but reduces reproductive fitness in females.

Early life milk diets shape infant gut microbiota: evidence of microbial plasticity in response to breast and formula milk.

This study shows that infant gut microbiota at 1 month are most responsive to dietary changes, while 18-month-olds show resilience, with formula affecting fewer metabolic pathways than breast milk.

Maternal gut Bifidobacterium breve modifies fetal brain metabolism in germ-free mice

This study shows that maternal colonization with Bifidobacterium breve during pregnancy alters fetal brain metabolism and expression of key pathways.

Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

This study shows that FMT from aged mice impairs spatial learning in young recipients by altering hippocampal proteins related to synaptic plasticity and neurotransmission.

Association between Apolipoprotein E genotype and the gut microbiome composition in humans and mice

This study investigates the association between APOE genotype and gut microbiome composition in humans and APOE-TR mice, finding specific microbial and metabolic differences linked to APOE alleles.