Acquisition of an immunosuppressive microenvironment after CAR-T therapy drives T-cell dysfunction and resistance
Marianna Ponzo, Lorenzo Drufuca, Chiara Buracchi, Marco M Sindoni, Silvia Nucera, Cristina Bugarin, Ramona Bason, Grazisa Rossetti, Raoul J.P. Bonnal, Cristian Meli, Benedetta Rambaldi, Federico Lussana, Silvia Ferrari, Alex Moretti, Giuseppe Dastoli, , Chiara Francesca Magnani
This study shows that CAR-T therapy induces an immunosuppressive microenvironment, leading to T-cell dysfunction and resistance in B-ALL patients.
Journal for ImmunoTherapy of Cancer · Oct 1, 2025Peer-reviewedImmunology