Author

Raoul J.P. Bonnal

IFOMORCID 0000-0002-2123-6536Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Raoul J.P. Bonnal1 paper

Biology Disciplines

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Cancer Biology· 2 Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2

Frequent Co-Authors

Massimiliano PaganiiD· 2 shared Adrian AndronacheiD· 1 shared Alejandro Lopez Tobon· 1 shared Alessandra TucciiD· 1 shared Alessandro RambaldiiD· 1 shared Alex MorettiiD· 1 shared Andrea BiondiiD· 1 shared Andrés J.M. FerreriiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

Massimiliano PaganiORCID

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4 papers

Recent·Most cited

Acquisition of an immunosuppressive microenvironment after CAR-T therapy drives T-cell dysfunction and resistance

Marianna Ponzo, Lorenzo Drufuca, Chiara Buracchi, Marco M Sindoni, Silvia Nucera, Cristina Bugarin, Ramona Bason, Grazisa Rossetti, Raoul J.P. Bonnal, Cristian Meli, Benedetta Rambaldi, Federico Lussana, Silvia Ferrari, Alex Moretti, Giuseppe Dastoli, , Chiara Francesca Magnani

This study shows that CAR-T therapy induces an immunosuppressive microenvironment, leading to T-cell dysfunction and resistance in B-ALL patients.

Journal for ImmunoTherapy of Cancer · Oct 1, 2025Peer-reviewedImmunology

B cell receptor silencing reveals the origin of high-grade B cell lymphomas with MYC and BCL2 rearrangements

Gabriele Varano, Silvia Lonardi, Paola Sindaco, Ilaria Pietrini, Gaia Morello, Piera Balzarini, Filippo Vit, Hadas Neuman, Giorgio Bertolazzi, Silvia Brambillasca, Nicara C. Parr, Marco Chiarini, Silvia Bellesi, Elena Maiolo, Sabrina Giampaolo, , Stefano S Casola

This paper shows that high-grade B cell lymphomas with MYC and BCL2 rearrangements originate from BCR-silenced follicular lymphoma cells that acquire IGL::MYC translocations, leading to resistance to CD79B-targeting therapy.

Blood Cancer Discovery · May 22, 2025Peer-reviewedCancer Biology

Novel antiviral interferon sensitive genes unveiled by correlation-driven gene selection and integrated systems biology approaches.

Cristina Cheroni, Lara Manganaro, Lorena Donnici, Valeria Bevilacqua, Raoul J.P. Bonnal, Riccardo Lorenzo Rossi, Raffaele De Francesco

The paper identifies novel antiviral interferon-sensitive genes using correlation-driven gene selection and systems biology approaches in HCV-permissive cells.

Scientific Reports · Sep 10, 2021Peer-reviewedSystems Biology

Single cell derived organoids capture the self-renewing subpopulations of metastatic ovarian cancer

Tania Velletri, Emanuele Carlo Villa, Michela Lupia, Pietro Lo Riso, Raffaele Luongo, Alejandro Lopez Tobon, Marco De Simone, Raoul J.P. Bonnal, Saverio Minucci, Stefano Piccolo, Nicoletta Colombo, Massimiliano Pagani, Ugo Cavallaro, Giuseppe Testa

This study develops a method to grow single-cell derived ovarian cancer organoids from patient ascites, which retain key subpopulations and features of the original metastasis not seen in 2D cultures.

bioRxiv · Nov 30, 2018 · PreprintCancer Biology