Spatial gene expression of human coronary arteries revealed the molecular features of diffuse intimal thickening in explanted hearts
Boaz Li, Samuel Leung, Maria Elishaev, Wan-Ling Cheng, Giuseppe Mocci, Johan Björkegren, Chi K. Lai, Amrit Singh, Ying Wang
This study uses spatial transcriptomics to compare gene expression in intima and media of human coronary arteries, revealing dedifferentiated SMCs in DIT that differ from proinflammatory SMCs in atherosclerotic lesions.
International Journal of Molecular Sciences · Feb 24, 2025Peer-reviewedPathology