Christer Betsholtz

Artery Like Smooth Muscle Drives Contractile Function in Dural Venous Sinuses

The paper identifies artery-like smooth muscle cells in dural venous sinuses that actively regulate venous outflow through contractile function and calcium signaling.

Microglia Adopt Temporally Specific States after Irradiation, Correlating with Neuronal Asynchrony

This study tracks microglial state changes and neuronal asynchrony after irradiation in mice, showing delayed microglial responses and two phases of neuronal dysfunction.

A comprehensive molecular atlas of the cell types in the mouse liver

The paper creates a molecular atlas of mouse liver cell types using single-cell RNA sequencing, revealing new insights into hepatic endothelial and mesenchymal cells and their responses to fibrosis.

Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

This study shows that endothelial tip cells use hydrostatic pressure and actin polymerization to migrate and sprout blood vessels, with Aqp1a.1 and Aqp8a.1 playing a key role in this process.

Epigenetic modulators link mitochondrial redox homeostasis to cardiac function

The paper shows that IDH2, a mitochondrial enzyme, acts as a major antioxidant defense in cardiomyocytes, with its activity compensating for reduced expression in heart failure, and identifies an epigenetic mechanism linking oxidative stress to cardiac function.

Mural cell SRF controls pericyte migration, vessel patterning and blood flow

This study investigates the role of SRF in mural cells, showing its importance in pericyte migration, vessel patterning, and blood flow during development and disease.

Dandy Walker-like malformations in mutant mice demonstrate a role for PDGF-C/PDGFRα signalling in cerebellar development

The paper shows that PDGF-C/PDGFRα signaling is critical for cerebellar development, as its loss in mice causes hypoplasia, malformation, and ependymal denudation.

Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells

This study identifies that arterial mural cells provide survival and guidance cues via Cxcl12a/b and Vegfc to promote lymphatic endothelial cell migration in zebrafish.

Conserved and context-dependent roles for Pdgfrb signaling during zebrafish vascular mural cell development

The paper shows that Pdgfrb signaling is essential for mural cell development in zebrafish, similar to mice, and identifies context-dependent roles in vascular structures.

Akt is required for artery formation during embryonic vascular development

This study identifies Akt's role in dorsal aorta formation by showing it sustains arterial progenitor specification and segregation in zebrafish.

Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta

The paper characterizes S1PR1-regulated transcriptomes in aortic endothelial cells, revealing distinct subtypes and signaling mechanisms in arterial and lymphatic endothelium.

Sprouting and anastomosis in the Drosophila trachea and the vertebrate vasculature: similarities and differences in cell behaviour

The paper compares branching and anastomosis processes in Drosophila trachea and vertebrate vasculature, highlighting similarities and differences in cell behavior during network formation.