Effects of HMGCR deficiency on skeletal muscle development
Mekala Gunasekaran, Hannah R. Littel, Natalya M. Wells, Johnnie Turner, Gloriana Campos, Sree Venigalla, Elicia A. Estrella, Partha S. Ghosh, Audrey L. Daugherty, Seth A. Stafki, Louis M. Kunkel, Aileen Reghan Foley, Sandra C. Donkervoort, Carsten G. Bönnemann, Laura Toledo‐Bravo de Laguna, , Peter B. Kang
This study investigates the effects of HMGCR deficiency on skeletal muscle development through genetic knockdown in mice and Drosophila, revealing shared mechanisms in three HMGCR-related muscle diseases.
bioRxiv · May 6, 2024 · PreprintDevelopmental Biology