JAG2-related muscular dystrophy and Notch signaling dysfunction in muscle stem cells
Nam Chul Kim, Minoru Tanaka, Isabelle Draper, Hannah R. Littel, Mekala Gunasekaran, Johnnie Turner, Natalya M. Wells, Qasim Mujteba, Yoko Asakura, Peter B. Kang, Atsushi Asakura
This study investigates JAG2-related muscular dystrophy by examining the role of Notch signaling in muscle stem cells, finding that JAG2 variants disrupt both autocrine and paracrine Notch signaling, impairing muscle regeneration.
bioRxiv · Jul 23, 2025 · PreprintDevelopmental Biology