HER2-driven mammary tumorigenesis enhances bioenergetics despite reductions in mitochondrial content
Sara M. Frangos, Henver S. Brunetta, Dongdong Wang, Maria Joy Therese Jabile, Leslie M Jeffries, Grace Mencfeld, David W.L., William J. Muller, Cezar M. Khursigara, Kelsey H. Fisher‐Wellman, Jim Petrik, Gregory R. Steinberg, Graham P. Holloway
This study shows that HER2-driven mammary tumors have reduced mitochondrial content but increased respiration, suggesting HER2 signaling enhances mitochondrial bioenergetics independently of mitochondrial content.
bioRxiv · Nov 3, 2024Cancer Biology