Kelsey H. Fisher‐Wellman

This study shows trametinib causes mitochondrial injury and innate immune activation in mouse hearts, leading to cardiomyopathy and heart failure.

This study shows that deleting BAG3 in endothelial cells uniquely alters the proteome of specific organs, with the most significant changes in skeletal muscle.

This study shows miR-1 regulates metabolic flexibility in skeletal muscle by controlling pyruvate metabolism, with loss of miR-1 causing metabolic inflexibility and reduced endurance.

This study shows that inhibiting acid ceramidase (AC) enhances venetoclax's effectiveness in venetoclax-resistant AML by inducing a cytotoxic integrated stress response.

The paper develops a method to profile mitochondrial function in specific kidney segments from mice and humans under thermodynamic control, revealing segment-specific bioenergetic differences.

This study shows semaglutide improves mitochondrial energy efficiency in skeletal muscle by enhancing ATP production per oxygen consumed during weight loss.

This study identifies a bioenergetic mechanism in AML cells where mitochondria consume ATP to resist chemotherapy, offering a target for improving treatment.

This study shows that HER2-driven mammary tumors have reduced mitochondrial content but increased respiration, suggesting HER2 signaling enhances mitochondrial bioenergetics independently of mitochondrial content.

This study shows that mitochondrial cardiolipin deficiency disrupts electron transport chain function, leading to oxidative stress and promoting MASH in mice and humans.