P-Rex2 exhibits unique structural features and regulatory mechanisms distinct from the closely related RhoGEF P-Rex1
Lauren K. Anderson, Rohan Marde, Grace Muma, Veda Nayak, Chi Phan, Sheng Li, Jennifer N. Cash
This study determines the structure of P-Rex2 and identifies unique regulatory features compared to P-Rex1, revealing differences in autoinhibition and dynamics.
bioRxiv · Jan 5, 2026 · PreprintBiochemistry