Author

Jennifer N. Cash

University of California, DavisORCID 0000-0002-0277-7652Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Emma BarpaliD· 2 shared Lauren K. AndersoniD· 2 shared Sheng LiiD· 2 shared Chi Phan· 1 shared Grace Muma· 1 shared Herra G. MendozaiD· 1 shared Matthew Villanueva BragaiD· 1 shared Rohan MardeiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

Emma BarpalORCID

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3 papers

Recent·Most cited

Cryo-EM structure of the sub-50 kD PDZ-RhoGEF catalytic core-RhoA complex reveals an allosteric mechanism for GEF switch

Matthew Villanueva Braga, Emma Barpal, Sheng Li, Jennifer N. Cash

The paper determines the structure of the PDZ-RhoGEF catalytic core-RhoA complex and identifies an allosteric mechanism by which the GEF switch enhances activity.

bioRxiv · Oct 21, 2026 · PreprintBiochemistry

GEF me a break: the consequences of freezing Rho guanine-nucleotide exchange factor catalytic domains

Lauren K. Anderson, Emma Barpal, Herra G. Mendoza, Jennifer N. Cash

This study examines the effects of freezing on RhoGEF protein activity and stability, finding significant variability in activity but preserved thermostability, with no universal cryoprotectant solution.

bioRxiv · Apr 9, 2026 · PreprintBiochemistry

P-Rex2 exhibits unique structural features and regulatory mechanisms distinct from the closely related RhoGEF P-Rex1

Lauren K. Anderson, Rohan Marde, Grace Muma, Veda Nayak, Chi Phan, Sheng Li, Jennifer N. Cash

This study determines the structure of P-Rex2 and identifies unique regulatory features compared to P-Rex1, revealing differences in autoinhibition and dynamics.

bioRxiv · Jan 5, 2026 · PreprintBiochemistry