Sheng Li

Cryo-EM structure of the sub-50 kD PDZ-RhoGEF catalytic core-RhoA complex reveals an allosteric mechanism for GEF switch

The paper determines the structure of the PDZ-RhoGEF catalytic core-RhoA complex and identifies an allosteric mechanism by which the GEF switch enhances activity.

P-Rex2 exhibits unique structural features and regulatory mechanisms distinct from the closely related RhoGEF P-Rex1

This study determines the structure of P-Rex2 and identifies unique regulatory features compared to P-Rex1, revealing differences in autoinhibition and dynamics.

Human coronavirus HKU1 neutralization by glycan receptor mimicry

This study identifies a monoclonal antibody that neutralizes HCoV-HKU1 by mimicking sialic acid binding to block receptor engagement.

Human SerRS/SIRT2 complex structure reveals cross regulation between translation and NAD+ metabolism

The paper reveals a cross-regulation between translation and NAD+ metabolism through the interaction of SerRS and SIRT2, mediated by ADP-ribose.

SPACA6 structure reveals a conserved superfamily of gamete fusion-associated proteins

The paper determines the structure of SPACA6, a sperm protein critical for gamete fusion, and identifies it as a founding member of a conserved superfamily of gamete fusion-associated proteins.