Aggregation chimeras provide evidence of in vivo intercellular correction in ovine CLN6 neuronal ceroid lipofuscinosis (Batten disease)
Lucy A. Barry, Graham W. Kay, Nadia L. Mitchell, Samantha J. Murray, Nigel P. Jay, David N. Palmer
This study uses aggregation chimeras to show that CLN6 disease in sheep is not cell intrinsic, as normal-like and recovering-like chimeras show reduced neuroinflammation and neurodegeneration.
PLoS ONE · Apr 11, 2022Peer-reviewedNeuroscience