Nadia L. Mitchell

This study identifies CLN6 as a glycerophosphoglycerol epimerase essential for BMP biosynthesis, showing its deficiency disrupts lysosomal hydrolase homeostasis and can be reversed by BMP precursor supplementation.

This study identifies BMP and LPG as biomarkers for CLN5 Batten disease using lipidomics, showing their depletion and elevation in disease models and patient samples.

This study shows dietary bioactive compounds alter the epigenetic and metabolic profiles of Lactobacillus acidophilus through specific gene regulation mechanisms.

This study uses aggregation chimeras to show that CLN6 disease in sheep is not cell intrinsic, as normal-like and recovering-like chimeras show reduced neuroinflammation and neurodegeneration.