EP3 signaling is decoupled from regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance
Michael D Schaid, Jeffrey Harrington, Grant Kelly, Sophia Sdao, Matthew J Merrins, Michelle E. Kimple
This study examines changes in β-cell cAMP and insulin secretion in response to obesity and insulin resistance, revealing complex EP3 signaling dynamics.
bioRxiv · Jul 10, 2020Pharmacology & Toxicology