Pharmacology & ToxicologybioRxiv
EP3 signaling is decoupled from regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance
Michael D Schaid, Jeffrey Harrington, Grant Kelly…·Michelle E. Kimple
This study examines changes in β-cell cAMP and insulin secretion in response to obesity and insulin resistance, revealing complex EP3 signaling dynamics.
DOI 10.1080/19382014.2023.2223327