Modular Nanobody Conjugates with Controlled Topology Using Genetically Encoded Non-canonical Amino Acids
Roman Adomanis, Nathan Phan, Grant Walter, Blaise R. Kimmel
This paper introduces a method to create bispecific nanobody conjugates with controlled topology using non-canonical amino acids, enabling precise domain orientation for immune checkpoint blockade therapy.
bioRxiv · Nov 27, 2025 · PreprintBioengineering