Blaise R. Kimmel

The paper develops an experimentally tuned protein-RNA score function for ROSETTA using Bayesian Optimization to improve energetic agreement with experimental data.

ProteinDock improves protein-protein docking reliability by integrating physics-based modeling with existing tools, achieving better results on benchmark datasets.

CovSite identifies reactive protein sites for covalent inhibitors using only structure and electrophile SMILES, achieving high accuracy and throughput.

This paper develops a yeast surface display platform to screen dimeric mammalian receptors, enabling high-throughput functional analysis of receptor activation and signaling.

This paper uses computational methods to analyze cisplatin binding in proteins, evaluates engineered MSH6 carriers, and compares DNA binding energies of protein-delivered versus systemic cisplatin.

This paper introduces a method to create bispecific nanobody conjugates with controlled topology using non-canonical amino acids, enabling precise domain orientation for immune checkpoint blockade therapy.

This study shows that macromolecular diABZI conjugates activate STING in vitro and in vivo, with similar potency to small molecule agonists, suggesting new strategies for STING agonist delivery.

This paper develops SAPCon, a polymer-drug conjugate that activates the STING pathway in tumors, enhancing immunotherapy efficacy by promoting an immunogenic microenvironment and improving tumor growth inhibition.

The paper optimizes and implements reverse beta-oxidation pathways in bacteria for carbon-negative synthesis of C4-C6 acids and alcohols, achieving high product titers in engineered strains.