Modeling of Epigenetic Modification-Induced Changes in CRX-dependent Genes cis-Regulatory Elements
Reafa A. Hossain, Nicholas R. Dunham, Megan E. Harris, Taylor Hutchinson, Justin Kidd, Lindsay R. Kohler, Gregory J. Salamon, Alexander L. Schmidt, Madison D. Thomas, Ray A. Enke, Christopher Berndsen
The paper models how DNA methylation affects CRX binding to regulatory elements of RHO and PDE6B genes in human ocular tissues, showing inverse correlations and structural changes in DNA grooves.
bioRxiv · Aug 22, 2017 · PreprintMolecular Biology