Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases
Min Kyung Shinn, Dylan T. Tomares, Vicky Liu, Avnika Pant, Yuanxin Qiu, Andreas Vitalis, You Jin Song, Yuna M. Ayala, Kiersten M. Ruff, Gregory W. Strout, Matthew D. Lew, Kannanganattu V. Prasanth, Rohit V. Pappu
The paper shows that SRSF1 and TDP-43 form microphases through protein interactions, and MALAT1 enhances this process by binding to SRSF1 microphases.
Cell · Dec 19, 2025Peer-reviewedBiophysics