Matthew D. Lew

The paper shows that SRSF1 and TDP-43 form microphases through protein interactions, and MALAT1 enhances this process by binding to SRSF1 microphases.

The paper investigates anisotropies in RNA-based biomolecular condensate interfaces, finding that purine-rich RNAs drive phase separation while pyrimidine-rich RNAs accumulate at interfaces, with distinct motion patterns observed using single-molecule imaging.

This study uses SMOLM to analyze A{beta}42 fibril architecture and dynamics, finding that order and heterogeneity correlate with growth and decay.

Deep-SMOLM improves 3D orientation and 2D position measurement of overlapping single molecules with high precision and speed.

The paper introduces pixOL, a method that improves the precision of measuring 3D orientation and localization of fluorescent molecules using engineered dipole-spread functions.

This paper introduces RoSE, an algorithm that minimizes structural bias in single-molecule super-resolution microscopy by improving localization accuracy and reducing false localizations.