Min Kyung Shinn

The paper shows that MALAT1 long noncoding RNA forms condensates with splicing factors to regulate hypoxia-induced alternative splicing near nuclear speckles.

The paper shows that SRSF1 and TDP-43 form microphases through protein interactions, and MALAT1 enhances this process by binding to SRSF1 microphases.

This study shows nuclear-import receptors suppress RNA-binding protein phase transitions by remodeling the dilute phase, preventing disease-linked aggregation.

The paper identifies how Xist Repeat A recruits SPEN via SR proteins to induce gene silencing, revealing a role for splicing factors in this process.

The paper introduces GIN, a resource that decodes molecular grammars of human intrinsically disordered regions (IDRs) and identifies their functional roles in biological processes and disease.

This study identifies sequence-encoded molecular grammars in synapsin-1 IDRs that drive condensation and generate pH gradients relevant for synaptic function.