Kannanganattu V. Prasanth

This study uses MINFLUX nanoscopy to show nuclear speckles are hierarchically organized into dynamic nanoscale interaction networks that regulate molecular dynamics.

This study uses MINFLUX nanoscopy to directly visualize MCM helicase activation and replisome coupling in human cells, showing sister replisomes remain coupled at ~40 nm during S phase.

This paper develops a stochastic kinetic model of splicing to predict mRNA isoform levels from site-specific splicing kinetics and validates it under normoxia and hypoxia.

The paper identifies U2AF2's role in intron retention of lncRNAs PURPL and MALAT1, showing how this process affects their localization and promotes cell proliferation and migration.

The paper shows that MALAT1 long noncoding RNA forms condensates with splicing factors to regulate hypoxia-induced alternative splicing near nuclear speckles.

The paper shows that SRSF1 and TDP-43 form microphases through protein interactions, and MALAT1 enhances this process by binding to SRSF1 microphases.

The paper models sequence-to-expression relationships in ER-bound enhancers to identify functional variants and regulatory mechanisms in the estrogen receptor transcriptional program.

This paper identifies hOrc6's role in promoting S-phase progression by facilitating mismatch repair complex assembly and activity at the replication fork.