Transcriptome analysis of genetically matched human induced pluripotent stem cells disomic or trisomic for chromosome 21.
Patrick K. Gonzales, Gin Fonte, Christine Roberts, Connor Jacobsen, Gretchen H. Stein, Christopher D. Link
This study analyzes transcriptome changes in trisomic and disomic human iPSCs for chromosome 21, identifying altered gene expression, alternative splicing, and repetitive element transcripts, and suggests trisomy may not limit neuronal differentiation.
PLoS ONE · Mar 27, 2018Peer-reviewedGenetics