Patrick K. Gonzales

The paper applies a bioinformatic pipeline to RNA-seq data from ALS patients and controls to identify novel virus-like sequences.

The paper shows heat shock in C. elegans increases antisense transcripts and downstream of gene transcripts, which accumulate as dsRNA foci overlapping with HSF-1 granules.

This study analyzes transcriptome changes in trisomic and disomic human iPSCs for chromosome 21, identifying altered gene expression, alternative splicing, and repetitive element transcripts, and suggests trisomy may not limit neuronal differentiation.