Christopher D. Link

This study characterizes human induced pluripotent stem cell-derived neurons co-cultured with astrocytes using MEAs, achieving strong network synchrony in six weeks.

This paper develops a nanoligomer-based therapy to treat neuroinflammation by targeting key inflammatory pathways, showing effectiveness in a mouse model.

This study shows that amyloid beta acts as a pro-inflammatory cytokine by synergizing with other cytokines to activate astrocytes in a manner distinct from high-dose effects.

The paper applies a bioinformatic pipeline to RNA-seq data from ALS patients and controls to identify novel virus-like sequences.

The paper shows heat shock in C. elegans increases antisense transcripts and downstream of gene transcripts, which accumulate as dsRNA foci overlapping with HSF-1 granules.

This study shows that loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation in C. elegans and other organisms.

This study analyzes transcriptome changes in trisomic and disomic human iPSCs for chromosome 21, identifying altered gene expression, alternative splicing, and repetitive element transcripts, and suggests trisomy may not limit neuronal differentiation.