Integrating UHPLC-MS and MALDI-MSI for Spatial Nucleoside Profiling in FFPE Breast Cancer: A Multimodal Molecular Pathology Framework
Jierong Wu, Sabrina Geisberger, Guido Mastrobuoni, Kamil Lisek, Sandra Raimundo, Grit Nebrich, Marta Grzeski, Nikolaus Rajewsky, Frederick Klauschen, Oliver Klein, Stefan Kempa
This paper develops a workflow integrating UHPLC-MS and MALDI-MSI to spatially map nucleosides in FFPE breast cancer tissues, revealing metabolic changes across tumor stages and validating findings in patient samples.
Analytical Chemistry · Sep 17, 2026Peer-reviewedCancer Biology