Cancer BiologyAnalytical ChemistryPeer-reviewed
Integrating UHPLC-MS and MALDI-MSI for Spatial Nucleoside Profiling in FFPE Breast Cancer: A Multimodal Molecular Pathology Framework
Jierong Wu, Sabrina Geisberger, Guido Mastrobuoni…·Stefan Kempa
This paper develops a workflow integrating UHPLC-MS and MALDI-MSI to spatially map nucleosides in FFPE breast cancer tissues, revealing metabolic changes across tumor stages and validating findings in patient samples.