Stefan Kempa

Depletion of the isocitrate dehydrogenase 3 subunit IDHA-1 licenses germ cell-to-neuron direct reprogramming in C. elegans

This study identifies IDHA-1 as a barrier to direct reprogramming of germ cells to neurons in C. elegans, showing metabolic and epigenetic mechanisms that maintain germ cell identity.

Integrating UHPLC-MS and MALDI-MSI for Spatial Nucleoside Profiling in FFPE Breast Cancer: A Multimodal Molecular Pathology Framework

This paper develops a workflow integrating UHPLC-MS and MALDI-MSI to spatially map nucleosides in FFPE breast cancer tissues, revealing metabolic changes across tumor stages and validating findings in patient samples.

Tau spreading coordinates intercellular lipid flux enhancing neuronal resilience to lipid toxicity

This study shows that spreading tau coordinates lipid homeostasis by promoting neuronal lipid efflux and enhancing resilience to lipid toxicity.

Butyrate Rescues Cardiac Metabolic Dysfunction in Hypertensive Heart Failure with Preserved Ejection Fraction

This study shows that butyrate improves diastolic function and reduces fibrosis in hypertensive HFpEF rats by serving as an alternative energy source.

Extensive folding variability between homologous chromosomes in mammalian cells

The paper uses GAM to study haplotype-specific 3D chromatin structures in mESCs, finding extensive allelic differences in chromatin architecture and gene expression mediated by Polycomb repression.

Sociality shapes mitochondrial adaptations supporting hypoxia tolerance

This study identifies mitochondrial adaptations in naked mole-rats that confer hypoxia resistance, linking social behavior to molecular evolution.

Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex

This study identifies Rbm10 as a splicing factor that facilitates heterochromatin assembly through its interaction with the Clr6 HDAC complex in fission yeast.

Kinetic modelling of quantitative proteome data predicts metabolic reprogramming of liver cancer

The paper uses a kinetic model of central carbon metabolism to predict metabolic reprogramming in liver cancer and validates findings through experiments.

Comprehensive identification and characterization of conserved small ORFs in animals

The paper identifies and characterizes conserved small ORFs in multiple animal species, finding novel micropeptides with evidence of translation and functional potential.