LSH-mediated resolution of R-loops mitigates transcription-replication conflicts to preserve genomic stability in prostate cancer cells
Kai Ni, Yu Zhang, Kun Chan Zheng, Jianwen Huang, Nuorong Xiong, Rong Liang, Yingxiao Chen, Honglin Jin, Youlong Hai, Li Wang, Jie Ma, Ranxing Yang, Guanggai Xia, Yueqing Bai, Lujie Song, , Qiang Fu
This study shows LSH resolves R-loops in prostate cancer cells, reducing transcription-replication conflicts and DNA damage, and identifies LSH as a potential therapeutic target.
bioRxiv · Jun 4, 2025 · PreprintCancer Biology