Activation of innate immune cGAS-STING pathway contributes to Alzheimer pathogenesis in 5xFAD mice
Xiaochun Xie, Guanqin Ma, Xiaohong Li, Jiebin Zhao, Zhen Zhao, Jianxiong Zeng
This study shows that the cGAS-STING pathway contributes to Alzheimer's disease progression in 5xFAD mice, and its inhibition reduces disease pathology.
Nature Aging · Jan 9, 2023Peer-reviewedNeuroscience