Zhen Zhao

This paper shows that glycated amyloid-beta causes mitochondrial dysfunction and Alzheimer's pathology by triggering the cGAS-STING pathway via VDAC1-dependent mtDNA release.

This study shows that neuronal SEL1L-HRD1 ERAD is critical for one-carbon metabolism, motor function, and survival, with loss leading to severe neurological defects.

This study uses a mouse-adapted SARS-CoV-2 strain to model long-term post-acute sequelae of COVID-19, finding persistent neurological and multi-organ impairments in mice after mild infection.

This study shows SARS-CoV-2 causes blood-brain barrier and choroid plexus barrier damage and vascular inflammation in mice, contributing to neurological complications.

This study uses high-intensity focused ultrasound to induce traumatic brain injury in human iPSC-derived cortical organoids, revealing key pathological features like tau phosphorylation and neurodegeneration.

This study uses Stereo-seq to analyze spatial transcriptomics in 5xFAD mice, linking neuronal transcriptomic changes to amyloid pathology at single-cell resolution.

This study shows that the cGAS-STING pathway contributes to Alzheimer's disease progression in 5xFAD mice, and its inhibition reduces disease pathology.

The paper identifies Atp13a5 as a specific marker for CNS pericytes in mice and develops a transgenic model to study their biology.

This study shows that microvascular injury from mild TBI accelerates Alzheimer-like pathology in mice, suggesting vascular repair could mitigate AD risk.

The paper identifies common molecular signatures of cerebrovascular injury in traumatic brain injury and aging using single-cell RNA-seq data from mouse models.