AAV-mediated CRISPR/Cas gene editing of retinal cells in vivo.
Sandy SC Hung, Vicki Chrysostomou, Amy Fan Li, Jeremiah KH Lim, Jiang-Hui Wang, Joseph E Powell, Leilei Tu, Maciej Daniszewski, Camden Lo, Raymond C Wong, Jonathan G Crowston, Alice Pebay, Anna E King, Bang V Bui, Guei-Sheung Liu, Alex Hewitt
This study uses AAV2 to deliver CRISPR/Cas components to retinal cells in Thy1-YFP mice, achieving an 84% reduction in YFP-positive cells without affecting retinal function.
Investigative Opthalmology & Visual Science · Jun 29, 2016Peer-reviewedGenomics