Maciej Daniszewski

The paper uses iPSC-derived RPE cells to compare molecular differences between AMD with and without reticular pseudodrusen, identifying distinct pathways and genetic influences.

This study optimizes in vitro neuronal microenvironments to reduce phototoxicity by testing culture conditions and imaging protocols over 33 days.

The paper demonstrates that village cultures of hiPSCs maintain consistent transcriptional profiles across uni- and village-cultured samples, enabling population-scale studies.

This study identifies genetic and molecular differences in RPE cells from geographic atrophy patients compared to controls using transcriptomic and proteomic analyses.

This study uses iPSC-derived retinal organoids to identify retinal ganglion cell-specific expression quantitative trait loci associated with primary open-angle glaucoma.

The paper identifies cell type-specific genetic control of gene expression in fibroblasts and iPSCs using single-cell RNA sequencing and eQTL mapping.

The paper identifies 46 genetic loci associated with retinal thickness using OCT images from UK Biobank, finding new links to foveal hypoplasia and visual acuity.

This study evaluates the ability of cerebral organoids derived from APOE-edited human pluripotent stem cells to model Alzheimer's disease features, finding limited APOE effect and high variability in organoid development.

This study compares the performance of BGI and Illumina sequencing technologies for single-cell RNA-sequencing, finding that BGI outperforms Illumina in cell and gene detection but similar in gRNA detection.

The paper characterizes the transcriptome of human stem cell-derived retinal ganglion cells using single-cell RNA sequencing, identifying three subpopulations with varying maturity levels.

This paper develops an automated system for maintaining and differentiating human pluripotent stem cells, enabling large-scale culture and reducing variability.

This study uses AAV2 to deliver CRISPR/Cas components to retinal cells in Thy1-YFP mice, achieving an 84% reduction in YFP-positive cells without affecting retinal function.